The Seahawks vs. Cardinals odds favor Seattle on the road as Arizona hosts a Week 2 matchup on Sunday on FOX.
Seattle opened its title defense with a 13-10 victory over New England. Quarterback Sam Darnold left in the first quarter and will miss the Week 2 trip to Arizona, according to the team. Drew Lock will start in his place.
After trailing 10-0 in the opener, the Seahawks closed with 13 straight points to defeat the Patriots for a second consecutive meeting. Seattle’s defense intercepted Drake Maye three times and limited New England to 10 points.
The Seahawks led the NFL last season by allowing 17.2 points per game, and the early signs point to another strong campaign on that side of the ball.
Arizona, meanwhile, delivered the biggest surprise of Week 1 by upsetting the Chargers on the road as a 9.5-point underdog. A defense that struggled in 2025 held Los Angeles to 14 points, 209 passing yards and 3.9 yards per rush, with three sacks and steady pressure throughout.
Jacoby Brissett was efficient, completing 27 of 37 attempts for 277 yards and a touchdown.
With that backdrop, can the Cardinals string together a second straight upset to start the year?
Seahawks vs. Cardinals odds
Moneyline
- Seahawks: -200 (bet $10 to win $15 total)
- Cardinals: +168 (bet $10 to win $26.80 total)
Spread
- Seahawks -3.5: -110 (bet $10 to win $19.09 total)
- Cardinals +3.5: -110 (bet $10 to win $19.09 total)
Over/Under
- Over 41.5: -110 (bet $10 to win $19.09 total)
- Under 41.5: -110 (bet $10 to win $19.09 total)
Seahawks vs. Cardinals prediction and pick
Drew Lock went 16-for-22 for 187 yards and a touchdown in relief in Week 1. New England did not game plan for him, but Arizona will have a full week to prepare for his tendencies.
It is only one game, yet the Cardinals looked improved in their first season under head coach Mike LaFleur. The defense appeared revitalized, and with a backup quarterback visiting, Arizona has a credible path to 2-0.
Offensively, the Cardinals have options, with Trey McBride, Jeremiyah Love and Marvin Harrison Jr. among the playmakers who can test Seattle.
The pick: Cardinals +3.5
How to watch Seahawks vs. Cardinals
- Date: Sunday, Sept. 20, 2026
- Time: 4:25 p.m. ET
- TV: FOX
- Stream: FOXSports.com, FOX Sports app, and promotional trials as available
- Location: State Farm Stadium, Glendale, AZ
For more on early-season wagering angles, see NFL Week 1 betting: Books brace for Cowboys, Bengals rush.
Fans can also follow official updates through the NFL and Seattle Seahawks websites.